BPS Filters

For the retention of bioburden contamination and to reduce microbials when sterilization is not required.

BPS cartridge and capsule filters are multipurpose products that excel in bioburden reduction, clarification and the prefiltration of aqueous fluids when sterilizing is not the goal. They consist of a single layer of Polyethersulfone (PES) membrane and deliver high flow and throughput across a wide pH range. These filters have low binding characteristics which is necessary when filtering fluids with high proteins and preservatives. For fluids with heavy microbial and particle contamination, an optional high-capacity PES prefilter can be integrated. BPS final layer pore sizes range from 0.03 to 1.2 µm and the integrated prefilter pore sizes range from 0.2 to 1.0 µm. CPF filters are designed with flexible configurations so you can achieve targeted results.

When sterile filtrate is the goal, and bacteria loads are high, the BPS is a very efficient standalone prefilter. Installing the BPS Filter (single or dual layer) protects the final filter from premature fouling, and extends its useful life.

BPS Filters are 100% integrity tested. These high-quality filters are flushed to remove manufacturing debris and reduce extractables. CPF filter devices scale from laboratory to full production using identical materials to ensure consistent results. BPS Capsule filters are available pre-sterilized.

Applications

  • Diagnostics
  • SVPs & LVPs
  • Water for Injection
  • Water Purification
  • Buffers
  • Sera/plasma
  • Vaccines
  • Ophthalmics

Features and Benefits

BPS is a family of biological grade, single and dual-layer Polyethersulfone (PES) filters. They are designed with a single Asymmetric PES membrane and have the option of adding a High Capacity PES prefilter layer.

  • Delivers high flow across a wide pH range
  • Low binding characteristics (much lower than cellulose acetate and nylon) for filtering liquids with preservatives and proteins that can adsorb to media
  • Optional integrated prefilter saves space by eliminating separate prefilter and housing
  • Prefilter extends the life of the final filter

Filtration Area

BPS filtration area

View Data Sheet for further product information:

  • Integrity test specifications
  • Flow rates for all pore sizes
  • Materials of construction
  • Operating parameters
  • Sanitization and sterilization
  • Regulation & compliance

Validation

BPS filters are validated for bioburden control using test procedures that comply with ASTM F 838-15(ae1) protocols for the determination of bacterial reduction in filters used for liquid filtration. The filters are challenged with the organisms listed below.

  • 0.03μm: Acholeplasma laidlawii 
  • 0.10μm: Brevundimonas diminuta
  • 0.22μm: Brevundimonas diminuta
  • 0.45μm: Serratia marcescens
  • 0.65μm: Saccharomyces cerevisiae

Validation Guides are available upon request.

Quality Assurance

BPS filters are 100% integrity tested. CPF filters are developed and manufactured under an ISO 9001:2015 certified Quality Management System and designed to be used in cGMP-compliant processes. 

BPS Cartridges 

Available from 5-40 inches in length with several end connections and O-ring options.  

BPS cartridge        Critical Process Filtration black and white capsule with etched logo 

BPS Capsules

These filters are BPS cartridges encapsulated in a polypropylene shell to minimize exposure to process fluids. A popular choice for single-use applications and can be disposed of easily. Sizes range from 2-30 inches in length. BPS Capsules are available pre-sterilized.

BPS capsule        Critical process black and white capsule with cutout to show cartridge etched logo 

BPS Mini-Capsule

Mini-capsules are designed for lab scale testing, process development and small batch production with a filtration area of 500 cm2. BPS Mini-Capsules are available pre-sterilized. 

BPS mini     Critical Process black and white mini capsule with etched logo