PPS Filters

Employed in the most stringent and critical applications, PPS filters are constructed with a double layered Polyethersulfone (PES) membrane for sterilizing aqueous liquids. PPS filters are validated and available in cartridge and capsule models. Pore sizes range from 0.03 to 1.2 µm and the filter sizes scale from laboratory to full production using identical materials to ensure consistent results.

The PPS filter’s low binding characteristics are well suited for filtering products with preservatives and protein solutions that can adsorb to media. These hydrophilic, double-layered filters are optimized for retention and provide added security. PPS filters deliver high flow and throughput with compatibility across a wide pH range. They are flushed to remove manufacturing debris and reduce extractables. Products are 100% integrity tested. PPS capsules are available pre-sterilized. 

Applications

• Parenterals
• Form & Fill 
• Diagnostics
• Cell Culture Media
• Buffers
• Sera/Plasma
• VTM
• Vaccines
• Biologicals
• Ophthalmics
• WFI and Bulk Water

Features and Benefits

PPS is a family of pharmaceutical grade, Polyethersulfone (PES) sterilizing filters.  This double layered, hydrophilic filter is optimized for retention and provides added security when compared to a single layer model. 

• Delivers high flow and throughput across a wide pH range
• Low binding characteristics (much lower than cellulose acetate and nylon) for filtering liquids with preservatives and proteins that can adsorb to media
• Pore sizes: 0.03 - 1.2 microns

Filtration Area

Quality Assurance

PPS filters are 100% integrity tested. CPF filters are developed and manufactured under an ISO 9001:2015 certified Quality Management System and designed to be used in cGMP-compliant processes. 

Validation

PPS filters are validated using test procedures that comply with ASTM F 838-15(ae1) protocols for the determination of bacterial retention in filters used for liquid filtration. The challenge level is a minimum of 107 organisms per cm2 of filter media. CPF filters have > 7-log removal when challenged with the organisms listed below (0.03μm, 0.10μm and 0.22μm meet the FDA definition of sterilizing grade filters). Validation Guides are available upon request.

• 0.03μm: Acholeplasma laidlawii 
• 0.10μm: Brevundimonas diminuta
• 0.22μm: Brevundimonas diminuta
• 0.45μm: Serratia marcescens
• 0.65μm: Saccharomyces cerevisiae

PPS Cartridges 

Available from 5-40 inches in length with several end connections and O-ring options.  For applications using elevated temperatures,  PPS/HT Cartridges can be used in processes up to 203°F. 

PPS Capsules

These filters are PPS cartridges encapsulated in a polypropylene shell to minimize exposure to process fluids. A popular choice for single-use applications and can be disposed of easily. Sizes range from 2-30 inches in length. PPS Capsules are available pre-sterilized.

PPS Mini-Capsule

Mini-capsules are designed for lab scale testing, process development and small batch production with a filtration area of 500 cm2. PPS Mini-Capsules are available pre-sterilized. 

View Data Sheet for further product information:

• Integrity test specifications
• Flow rates for all pore sizes
• Materials of construction
• Operating parameters
• Sanitization and sterilization
• Regulatory & compliance