Sterilizing & Bioburden Reduction Filters
With bioburden management beginning before the bioreactor and continuing downstream to final fill, Critical Process Filtration delivers high quality bioburden control and sterilizing filters made with PES membrane to assure a sterile product.
BPS Filters are made with PES membrane, available in single and dual layer configurations. They are designed to reduce bioburden contamination and are utilized in products with high proteins and preservatives that can adsorb to media.
Our PPS Filters consist of a double layer of PES for the most critical applications and have low binding characteristics for filtering ingredients with preservatives and protein solutions that can adsorb to media. For increased capacity when filtering liquids with high particle loads, HPPS Filters provide a dual layer PES membrane configuration - an integrated prefilter layer with an asymmetric PES final filter. This 2-in-1, prefilter and sterilizing model is a good solution when space is limited to one housing.
Where mycoplasma is an issue, CPF recommends 0.03 micron filters for capturing small deformable particles that might penetrate through a traditional 0.2 micron filter. Use of 0.03 micron filters in a validated process ensures sterile, mycoplasma-free serum and plasma.
If endotoxin removal is necessary, the PPC Filter sterilizes and is positively charged to remove gram-negative bacteria debris.
Protecting tank contents and the process environment
CPF's PTR Filters can prevent environmental and process gas sources of bacteria and contaminants. These hydrophobic sterilizing filters are made with Polytetrafluoroethylene (PTFE) membrane to capture microbials as air/gas enters a tank. Likewise, as air/gas is released from the tank, the PTR filter protects operators in the surrounding work space.