Installing the right train of prefilters and sterilizing filters based on the blood component's characteristics and bacteria load will assure product sterility before quality control testing.
Sterilizing & Endotoxin Removal
PPS filters, constructed with a double layer of Polyethersulfone (PES) will meet your requirement to remove all bacteria with a 0.22 or 0.10 micron configuration. If higher flow rates are driving your decision, SPS Filters made with a single layer of PES is your better choice. When starting with a less refined product, HPPS Filters with an integrated prefilter will increase capacity and sterilize your fluids without requiring another filter.
Where mycoplasma is an issue, CPF recommends 0.03 micron filters for capturing small deformable particles that might penetrate through a traditional 0.2 micron filter. Use of 0.03 micron filters in a validated process ensures sterile, mycoplasma-free serum and plasma.
When keeping endotoxins out of your process is required, they can be eliminated with either of our positively charged endotoxin removal filters. For both sterilization and removing endotoxin, PPC Filters, made with a double layer of PES, are validated for absolute bacteria retention and also capture negatively charged debris. Depending on level of contaminant and flow rate, PPC filters will typically exhibit > 3-log removal of endotoxin.
If you are already using a sterilizing filter, our general purpose GPC Filter, made from a single layer of PES, will capture negatively charged biological contaminants such as endotoxins and other cell fragments in aqueous fluids.
Protecting tank contents and the process environment
CPF's PTR filters can prevent environmental and process gas sources of bacteria and contaminants. These hydrophobic sterilizing filters are made with Polytetrafluoroethylene (PTFE) membrane to capture microbials as air/gas enters a tank. Likewise, as air/gas is released from the tank, the PTR filter protects operators in the surrounding work space.