Critical Process Filtration Blog

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Blog Feature

Filter System Design | Problem Solving

By: Critical Process Filtration
April 5th, 2023

One of the first questions many customers ask when evaluating filtration solutions is, “How many filters will I need?” Getting to the correct answer requires consideration of many factors.

Blog Feature

Problem Solving | Filtration Troubleshooting

By: Critical Process Filtration
March 21st, 2023

When a process does not perform as expected, asking the question “What changed” is the best place to start. For over 20 years we have been helping customers find the culprit in their filtration process when suddenly results go awry. A robust, professionally designed filtration system will work the same way, every day, until something changes. Intentional changes are easy to figure out, but what happens when something changes in the process and no one is aware until a batch is compromised? That’s a critical point for process review and troubleshooting. Here are the top questions we ask in determining "what changed" so we can help get your operation back on track.

Blog Feature

Final Filtration | Bacteria Reduction/Removal | Beer Filtration | Beverage Processing | How-To | Problem Solving

By: Critical Process Filtration
March 9th, 2023

The alcohol, low oxygen content, relatively low pH, hops extracts (alpha-acids) and dissolved carbon dioxide in beer inhibit the growth of pathogenic bacteria. That is why beer has been a safe drinking alternative for so many centuries. However, some microorganisms can survive and even thrive in beer and spoil the flavor and aroma of any good brew.

Blog Feature

Filter System Design | How-To | Problem Solving

By: Critical Process Filtration
March 1st, 2023

DEVELOPMENT, SCALE-UP, AND VALIDATION OF PHARMACEUTICAL FILTRATION PROCESSES Our Technical Service Team performs application testing for a wide variety of fluids from water to complex chemical solutions. No matter what industry the customer is part of, we carefully document our test results and make recommendations based on those results. We get it right the first time.  For pharmaceutical applications, whether removing particles from ingredients entering the plant or sterilizing parenteral products, the testing, and documentation we routinely create help show the consistent performance required for the validation of the process.

Blog Feature

Bacteria Reduction/Removal | Integrity Testing | Water Intrusion Integrity Test | Diffusion Integrity Test

By: Critical Process Filtration
February 12th, 2023

If you’re using filtration to remove bacteria from your process, integrity testing will provide you with data to ensure product quality. Did you know you can perform integrity testing in-house without the huge expense of buying commercial equipment?

Blog Feature

Pharmaceutical Filter Prices

By: Critical Process Filtration
November 9th, 2022

When comparing pharmaceutical filters, you're likely to find a wide variation in pricing. You may find yourself wondering -- what's the real difference between them? How can one sterilizing filter cost $500 and its equivalent cost $200? And in the case of a larger size, one can cost $1,000 while its equivalent costs $500. As a manufacturer of process filters for over 20 years, Critical Process Filtration, Inc. competes with large, well-known filtration companies and is a supplier to many distributors. We have been asked how our filters, delivering the same performance, can be so much less expensive than our larger competitors. Visually, sterilizing cartridge filters with pleated PES (polyethersulphone) membrane and polypropylene support media and hardware look pretty much the same from manufacturer to manufacturer. The end cap or cage designs may vary to differentiate between manufacturers, but that's not the reason for the drastic cost differences. Comparing product specifications between suppliers shows that all sterilizing filters are integrity tested, with very similar diffusion and flow specifications. They are also validated to ensure the integrity test correlates to bacteria removal. So, if they look the same, and perform the same, what accounts for pricing differences of 50% or more? To try to answer this question, we will detail the factors that impact the cost of filters in your market and why pharmaceutical companies should care.

Blog Feature

Bacteria Reduction/Removal | Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Tank Vent Filters | Food & Beverage Filtration

By: Critical Process Filtration
September 27th, 2022

   Most Commonly Asked Filtration Question Series     The risks of not using vent filters on holding and mixing tanks are real and costly. Unfortunately, we usually hear from a company after they've experienced serious issues because they did not install vent filters. So, this article is written for those not yet using vent filters on their tanks. It will address the most common issues/questions we're asked on this topic with the hope of sparing you a process headache you don't need. Many processes require the use of tanks for holding ingredients to be added into the process, mixing ingredients, or holding the final product pending final filtration and filling. During the course of normal operations, these tanks will be filled and emptied many times.

Blog Feature

Pharmaceutical Filtration | Biopharmaceutical Filtration | Filters in Water Treatment Systems | Pharmaceutical Water | Food & Beverage Filtration

By: Critical Process Filtration
August 29th, 2022

Extractables and Leachables, these terms are a part of the manufacturing process of new medicines and other areas of such. These terms are very commonly misunderstood by one another and they both gave their distinct characteristics, which can be traced through the whole supply chain.  The definitions of these are not balanced. They overlap and have different utilization, and situations in the manufacturing process must be categorized to highlight the weight and necessity of both extractables and leachables.

Blog Feature

Particle Filtration | Nominal vs Absolute Filters

By: Critical Process Filtration
June 27th, 2022

While filter ratings are an important indication of how well the filter will remove particles of varying sizes from a fluid or gas, it is important to note that nominally rated filters from different manufacturers can have the same rating, but yield different results. The opposite is also true – nominally rated filters from different suppliers can have different ratings, yet yield the same result. Naturally, this can create confusion and impact your filter buying decisions. When these situations arise, we recommend that focusing on achieving the targeted performance of a filter over the rating will yield the best results. With that in mind, let’s start with differentiating between the two types of ratings that indicate pore size and efficiency in removing particulates -- Nominal and Absolute ratings.