Critical Insights Blog

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How-To | Integrity Testing | Pressure Decay Test

By: Critical Process Filtration
May 12th, 2022

While filter ratings are a simpler integrity test for less critical applications is a Pressure Decay Test. This requires the same air (or nitrogen) source and an accurate pressure gauge but does not require a mass flow meter. This type of test can be performed before and after use and is sensitive enough to detect very small leaks.

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Sterilizing Filtration | Endotoxin Removal | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
March 11th, 2022

Your process requires a sterile end product. To achieve this, you plan on installing a sterilizing filter. But with so many choices, how do you choose the best one? Some suppliers offer single-layer membrane sterilizing filters. Others may offer filters with two layers of membrane, sometimes with different pore sizes (a larger pore size in front of the final sterilizing filter), or two layers of identical material in the same pore size. Each plays a specific role in reaching your sterilizing requirements. This article will discuss the many factors in choosing a sterilizing filter and list our products that deliver targeted retention.

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Sterilizing Filtration | Pharmaceutical Filtration | Biopharmaceutical Filtration | Pharmaceutical Water | Improve Filter Performance | Bioprocessing | Biotechnology Filtration | Filter Equivalents

By: Critical Process Filtration
January 4th, 2022

How to evaluate a replacement filter equivalent to the one you're using now. For any number of reasons, you’re looking for a new filter supplier. If your current filtration performance is satisfactory, replacing the filters with the correct equivalent will do. But if you need to improve filter performance, a different configuration of your current filter or a different type of filter will be the solution. Either way, a quality supplier should take the time to determine exactly what equivalent means to you and help you identify the appropriate filter(s).

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Problem Solving | Filter Ratings | Nominal vs Absolute Filters

By: Critical Process Filtration
December 6th, 2021

Pore size ratings are an important indicator of how well a filter will remove particles of varying sizes from a liquid or gas. It is just as important to take into consideration whether the filter rating is Absolute or Nominal, and the removal efficiency stated for the rated pore size, as not all nominal rated filters are created equal.

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Forward Flow Diffusion Test | Integrity Testing | Water Intrusion Integrity Test | Bubble Point Integrity Test | Pressure Decay Test

By: Critical Process Filtration
July 1st, 2020

   Most Commonly Asked Filtration Question Series      Integrity Testing is a requirement of suppliers selling absolute-rated membrane cartridge filters for microbial reduction or removal of yeast and mold. Test results are validated to remove specific organisms and a certificate is included with each product proving the quality of the filter. In addition to vendor testing, manufacturers in different industries perform their own Integrity Tests for critical processes. In pharmaceutical and bioprocessing, industry regulations call for Integrity Testing at prescribed intervals in a process. In the Food & Beverage industry, although not mandatory, Integrity Testing is a strategic move to assuring product safety and quality. Today we'll discuss the need and steps for in-process integrity testing.

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Reduce Operating Costs | Improved Filter Efficiency | Prefiltration

By: Critical Process Filtration
June 18th, 2020

    Most Commonly Asked Filtration Question Series     In every process, the final filter plays the most critical role in assuring that your filtrate meets expectations and requirements. It is typically the most expensive filter as well. The useful life span of a final filter will determine your change-out schedule and impact your filtration costs. But what if you could extend the life of your final filters, improve process efficiency, and lower filtration costs? With the right Prefiltration strategy you can. We've been helping process teams since 1998 by offering real business and technical filtration solutions that achieve our customers' goals. Critical Process Filtration is a mid-sized filter manufacturer that has designed and shipped millions of filters to hundreds of companies producing pharmaceuticals, food, chemicals, electronics, medical supplies, and more. We have complied with the most commonly asked questions and situations that most filtration operations experience. Today we'll explore Prefiltration and how it impacts process efficiency and costs.

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Sterilizing Filtration | Clarification and Prefiltration | Problem Solving | Tank Vent Filters | Fast Delivery of Process Filters

By: Critical Process Filtration
September 25th, 2019

It happens. Unfortunately, more often than anyone would like. You are about to process a new batch of fluids or adjust the current load and inventory status reports show that only half of the filters needed are in stock. Your next regular delivery is two months out. A phone call to your vendor reveals they can expedite your next order and it will arrive in six weeks. What do you do? You jump into crisis management mode, determined to figure out – how else can we get filters delivered fast? The answer to that question is now driving your business goal for that batch or shall we say, the cart is now leading the horse. In this article, we will discuss options for improving delivery strategies and putting the horse back in the lead.

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Final Filtration | Bacteria Reduction/Removal | Filters in Water Treatment Systems | Pharmaceutical Water | Particle Filtration

By: Critical Process Filtration
May 16th, 2019

The goal of pharmaceutical water system operators is to produce bacteria-free water that meets or exceeds required purity standards. Water systems use several filters to protect system components and to assure that the water dispensed for use is free of bacteria and most other particle contaminants.