Integrity Testing of Hydrophilic Membrane Filters: Diffusive Flow Test
Preface All integrity test procedures outlined below should be followed when performing integrity testing of membrane filters only. Use of these procedures on other types of filters such as polypropylene or glass fiber cartridges will not give
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The Difference Between Sterilizing Fluids and Endotoxin Removal
You’ve sanitized your system. You have sterilizing grade filters installed at key points in your process. Your bioburden measurements are low, but you still have endotoxin issues. What’s going on?
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How many filters will be needed in my process?
One of the first questions many customers ask when evaluating filtration solutions is, “How many filters will I need?” Getting to the correct answer requires consideration of many factors.
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Case Study: Intermittent Premature Filter Fouling Solved
Premature fouling is caused by an excess of particles in the fluid that clogs a filter earlier than its expected life cycle. Typically, the problem will appear every time the fluid passes through the employed filter, and sometimes it happens
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My filtration performance isn’t the same. What changed?
When a process does not perform as expected, asking the question “What changed?” is the best place to start. For over 20 years, we have been helping customers find the culprit in their filtration process when suddenly results go awry. A robust,
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Protect Beer Quality by Removing Spoilage Organisms
The alcohol, low oxygen content, relatively low pH, hops extracts (alpha-acids) and dissolved carbon dioxide in beer inhibit the growth of pathogenic bacteria. That is why beer has been a safe drinking alternative for so many centuries. However,
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Filtration Process Development and Validation in Pharmaceuticals
DEVELOPMENT, SCALE-UP, AND VALIDATION OF PHARMACEUTICAL FILTRATION PROCESSES Our Technical Service Team performs application testing for a wide variety of fluids, from water to complex chemical solutions. No matter what industry the customer is part
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Filter Integrity Testing without Capital Expenditure
If you’re using filtration to remove bacteria from your process, integrity testing will provide you with data to ensure product quality. Did you know you can perform integrity testing in-house without the huge expense of buying commercial equipment?
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The Price of Pharmaceutical Filters - Why Do Costs Vary So Much?
When comparing pharmaceutical filters, you're likely to find a wide variation in pricing. You may find yourself wondering -- what's the real difference between them? How can one sterilizing filter cost $500 and its equivalent cost $200? And in the
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Risks of Not Using Vent Filters on Holding/Mixing Tanks
The risks of not using vent filters on holding and mixing tanks are real and costly. Unfortunately, we usually hear from a company after they've experienced serious issues because they did not install vent filters. So, this article is written for
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When nominal filter ratings differ, yet yield the same results.
While filter ratings are an important indication of how well the filter will remove particles of varying sizes from a fluid or gas, it is important to note that nominally rated filters from different manufacturers can have the same rating, but yield
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Pressure Decay Testing. Why, When, and How?
A simpler integrity test for less critical applications is a Pressure Decay Test. This requires the same air (or nitrogen) source and an accurate pressure gauge but does not require a mass flow meter. This type of test can be performed before and
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